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Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II.
The role of DNA topoisomerases in eucaryotic class III gene transcription in vitro has been studied through the use of inhibitory drugs and antisera to DNA topoisomerases I and II. The DNA topoisomerase II inhibitors, novobiocin and coumermycin AI, were found to inhibit transcription of cloned 5S an...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1986
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC339644/ https://ncbi.nlm.nih.gov/pubmed/3008085 |
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