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Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II.

The role of DNA topoisomerases in eucaryotic class III gene transcription in vitro has been studied through the use of inhibitory drugs and antisera to DNA topoisomerases I and II. The DNA topoisomerase II inhibitors, novobiocin and coumermycin AI, were found to inhibit transcription of cloned 5S an...

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Foilsithe in:Nucleic Acids Res
Príomhúdar: Gottesfeld, J M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 1986
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3008085/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.5.2075
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