ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca(2+) and Mg(2+) Regulation

Here we investigate how ß-adrenergic stimulation of the heart alters regulation of ryanodine receptors (RyRs) by intracellular Ca(2+) and Mg(2+) and the role of these changes in SR Ca(2+) release. RyRs were isolated from rat hearts, perfused in a Langendorff apparatus for 5 min and subject to 1 min...

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Detalhes bibliográficos
Main Authors: Li, Jiao, Imtiaz, Mohammad S., Beard, Nicole A., Dulhunty, Angela F., Thorne, Rick, vanHelden, Dirk F., Laver, Derek R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606165/
https://ncbi.nlm.nih.gov/pubmed/23533585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058334
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