Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach

Multidrug-resistant bacterial infections are commonly treated with glycopeptide antibiotics such as teicoplanin. This drug inhibits bacterial cell-wall biosynthesis by binding and sequestering a cell-wall precursor: a d-alanine-containing peptide. A carrier-protein strategy was used to crystallize t...

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Main Authors: Economou, Nicoleta J., Zentner, Isaac J., Lazo, Edwin, Jakoncic, Jean, Stojanoff, Vivian, Weeks, Stephen D., Grasty, Kimberly C., Cocklin, Simon, Loll, Patrick J.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606034/
https://ncbi.nlm.nih.gov/pubmed/23519660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912050469
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