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The high resolution structure of tyrocidine A reveals an amphipathic dimer

Tyrocidine A, one of the first antibiotics ever to be discovered, is a cyclic decapeptide that binds to membranes of target bacteria, disrupting their integrity. It is active against a broad spectrum of Gram-positive organisms, and has recently engendered interest as a potential scaffold for develop...

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Detalhes bibliográficos
Main Authors: Loll, Patrick J., Upton, Elizabeth C., Nahoum, Virginie, Economou, Nicoleta J., Cocklin, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980540/
https://ncbi.nlm.nih.gov/pubmed/24530898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.01.033
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