A carrier protein strategy yields the structure of dalbavancin

Many large natural product antibiotics act by specifically binding and sequestering target molecules found on bacterial cells. We have developed a new strategy to expedite the structural analysis of such antibiotic-target complexes, in which we covalently link the target molecules to carrier protein...

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Bibliografiske detaljer
Main Authors: Economou, Nicoleta J., Nahoum, Virginie, Weeks, Stephen D., Grasty, Kimberly C., Zentner, Isaac J., Townsend, Tracy M., Bhuiya, Mohammad W., Cocklin, Simon, Loll, Patrick J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304006/
https://ncbi.nlm.nih.gov/pubmed/22352468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208755j
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