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A carrier protein strategy yields the structure of dalbavancin
Many large natural product antibiotics act by specifically binding and sequestering target molecules found on bacterial cells. We have developed a new strategy to expedite the structural analysis of such antibiotic-target complexes, in which we covalently link the target molecules to carrier protein...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304006/ https://ncbi.nlm.nih.gov/pubmed/22352468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208755j |
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