Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells

Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the p...

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Bibliographic Details
Main Authors: Xu, Libin, Korade, Zeljka, Rosado, Dale A., Mirnics, Karoly, Porter, Ned A.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605989/
https://ncbi.nlm.nih.gov/pubmed/23381570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M035733
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