7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome

Smith-Lemli-Opitz syndrome (SLOS) is a recessive disease characterized by markedly elevated levels of 7-dehydrocholesterol (7-DHC) and reduced levels of cholesterol in tissues and fluids of affected individuals, due to defective 3β-hydroxysterol-Δ(7)-reductase (Dhcr7). Treatment of Sprague-Dawley ra...

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Bibliographic Details
Main Authors: Xu, Libin, Sheflin, Lowell G., Porter, Ned A., Fliesler, Steven J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340457/
https://ncbi.nlm.nih.gov/pubmed/22425966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2012.03.001
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