The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that cause increased acetylation of core histones and nonhistone proteins leading to modulation of gene...

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Autori principali: Crisanti, M. Cecilia, Wallace, Africa F., Kapoor, Veena, Vandermeers, Fabian, Dowling, Melissa L., Pereira, Luana P., Coleman, Kara, Campling, Barbara G., Fridlender, Zvi G., Kao, Gary D., Albelda, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605895/
https://ncbi.nlm.nih.gov/pubmed/19671764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0138
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