FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models

BACKGROUND AND PURPOSE: The free fatty acid FFA1 receptor and GPR120 are GPCRs whose endogenous ligands are medium- and long-chain FFAs, and they are important in regulating insulin and GLP-1 secretion respectively. Given that the ligands of FFA1 receptor and GPR120 have similar properties, selectiv...

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Detalhes bibliográficos
Main Authors: Takeuchi, Masato, Hirasawa, Akira, Hara, Takafumi, Kimura, Ikuo, Hirano, Tatsuya, Suzuki, Takayoshi, Miyata, Naoki, Awaji, Takeo, Ishiguro, Masaji, Tsujimoto, Gozoh
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605867/
https://ncbi.nlm.nih.gov/pubmed/22639973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02052.x
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