Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

Cytoplasmic accumulation and nuclear clearance of TDP-43 characterize familial and sporadic forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, suggesting that either loss or gain of TDP-43 function, or both, cause disease formation. Here we have systematically compared los...

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Main Authors: Diaper, Danielle C., Adachi, Yoshitsugu, Sutcliffe, Ben, Humphrey, Dickon M., Elliott, Christopher J.H., Stepto, Alan, Ludlow, Zoe N., Vanden Broeck, Lies, Callaerts, Patrick, Dermaut, Bart, Al-Chalabi, Ammar, Shaw, Christopher E., Robinson, Iain M., Hirth, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605831/
https://ncbi.nlm.nih.gov/pubmed/23307927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt005
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