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Does a loss of TDP-43 function cause neurodegeneration?
In 2006, TAR-DNA binding protein 43 kDa (TDP-43) was discovered to be in the intracellular aggregates in the degenerating cells in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two fatal neurodegenerative diseases [1,2]. ALS causes motor neuron degeneration leadin...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419078/ https://ncbi.nlm.nih.gov/pubmed/22697423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-27 |
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