Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zebrafish and mouse demonstrate that the neuronal dys...

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Main Authors: Diaper, Danielle C., Adachi, Yoshitsugu, Lazarou, Luke, Greenstein, Max, Simoes, Fabio A., Di Domenico, Angelique, Solomon, Daniel A., Lowe, Simon, Alsubaie, Rawan, Cheng, Daryl, Buckley, Stephen, Humphrey, Dickon M., Shaw, Christopher E., Hirth, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766182/
https://ncbi.nlm.nih.gov/pubmed/23727833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt243
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