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Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone is only feasible in a minority of cases, leaving many patients without an effective treatment. We report the potential efficacy of gene therapy in focal neocortical epilepsy using a rodent model in which epil...

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Autors principals: Wykes, Robert C., Heeroma, Joost H., Mantoan, Laura, Zheng, Kaiyu, MacDonald, Douglas C., Deisseroth, Karl, Hashemi, Kevan S., Walker, Matthew C., Schorge, Stephanie, Kullmann, Dimitri M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605784/
https://ncbi.nlm.nih.gov/pubmed/23147003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004190
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