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Chemical–genetic attenuation of focal neocortical seizures

Focal epilepsy is commonly pharmacoresistant, and resective surgery is often contraindicated by proximity to eloquent cortex. Many patients have no effective treatment options. Gene therapy allows cell-type specific inhibition of neuronal excitability, but on-demand seizure suppression has only been...

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Detalhes bibliográficos
Main Authors: Kätzel, Dennis, Nicholson, Elizabeth, Schorge, Stephanie, Walker, Matthew C., Kullmann, Dimitri M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050272/
https://ncbi.nlm.nih.gov/pubmed/24866701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4847
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