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Non-canonical Guanine recognition mediates KSRP regulation of Let-7 biogenesis
Let-7 is an important tumor-suppressive microRNA that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human KSRP protein to Let-7 miRNA precursors positively regulates their processing to mature Let-7, thereby contributin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605776/ https://ncbi.nlm.nih.gov/pubmed/23142982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2427 |
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