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PHOSPHORYLATION-MEDIATED UNFOLDING OF A KH DOMAIN REGULATES KSRP LOCALISATION VIA 14-3-3 BINDING
The AU-rich-element (ARE)–mediated mRNA degradation activity of the RNA-binding K-homology Splicing Regulator Protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the cell phosphorylation promotes the interaction between KSRP and 14-3-3ζ protein and im...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858377/ https://ncbi.nlm.nih.gov/pubmed/19198587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1558 |
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