Mice deficient in dihydrolipoyl succinyltransferase show increased vulnerability to mitochondrial toxins

The activity of a key mitochondrial tricarboxylic acid cycle enzyme, α-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyltransferase (DLST) component is unique to KGDHC. DLST(+/-) mice showed reduced...

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Autores principales: Yang, Lichuan, Shi, Qingli, Ho, Daniel J., Starkov, Anatoly A., Wille, Elizabeth J., Xu, Hui, Chen, HL, Zhang, Steven, Stack, Cliona M., Calingasan, Noel Y., Gibson, Gary E., Beal, M. Flint
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605719/
https://ncbi.nlm.nih.gov/pubmed/19660549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.07.023
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