HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

Wnt signaling plays a pivotal role in embryogenesis and tissue homeostasis. Dishevelled (Dvl) is a central mediator for both Wnt/β-catenin and Wnt/planar cell polarity pathways. NEDD4L, an E3 ubiquitin ligase, has been shown to regulate ion channel activity, cell signaling, and cell polarity. Here,...

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Detaylı Bibliyografya
Asıl Yazarlar: Ding, Yi, Zhang, Yan, Xu, Chao, Tao, Qing-Hua, Chen, Ye-Guang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605647/
https://ncbi.nlm.nih.gov/pubmed/23396981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433185
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