Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a secreted protein that binds to the epidermal growth factor-like-A domain of the low density lipoprotein receptor (LDLR) and mediates LDLR degradation in liver. Gain-of-function mutations in PCSK9 are associated with autosomal dominant hyperc...

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Autori principali: Kosenko, Tanja, Golder, Mia, Leblond, Geoffrey, Weng, Willy, Lagace, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Lipids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605646/
https://ncbi.nlm.nih.gov/pubmed/23400816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421370
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