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BMP Induces Cochlin Expression to Facilitate Self-renewal and Suppress Neural Differentiation of Mouse Embryonic Stem Cells

BMP4 maintains self-renewal of mouse embryonic stem cells (ESCs) in collaboration with LIF. Here, we report the identification of a novel key BMP target gene, cochlin (Coch) in mouse ESCs. Coch can be significantly up-regulated by BMP4 specifically in ESCs but not in somatic differentiated cells, an...

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書誌詳細
主要な著者: Zhang, Jianping, Fei, Teng, Li, Zhongwei, Zhu, Gaoyang, Wang, Lu, Chen, Ye-Guang
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605624/
https://ncbi.nlm.nih.gov/pubmed/23344953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433995
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