Significant differences in genotoxicity induced by retrovirus integration in human T cells and induced pluripotent stem cells

Retrovirus is frequently used in the genetic modification of mammalian cells and the establishment of induced pluripotent stem cells (iPSCs) via cell reprogramming. Vector-induced genotoxicity could induce profound effect on the physiology and function of these stem cells and their differentiated pr...

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Bibliographic Details
Main Authors: Zheng, Weiyan, Wang, Yingjia, Chang, Tammy, Huang, He, Yee, Jiing-Kuan
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605218/
https://ncbi.nlm.nih.gov/pubmed/23376452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2013.01.009
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