AAV9.I-1c Delivered Via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodelling

BACKGROUND: Heart failure is characterised by impaired function and disturbed Ca(2+) homeostasis. Transgenic increases in inhibitor-1 activity have been shown to improve Ca(2) cycling and preserve cardiac performance in the failing heart. The aim of this study is to evaluate the effect of activating...

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Main Authors: Fish, Kenneth M., Ladage, Dennis, Kawase, Yoshiaki, Karakikes, Ioannis, Jeong, Dongtak, Ly, Hung, Ishikawa, Kiyotake, Hadri, Lahouaria, Tilemann, Lisa, Muller-Ehmsen, Jochen, Samulski, R. Jude, Kranias, Evangelia G., Hajjar, Roger J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605211/
https://ncbi.nlm.nih.gov/pubmed/23271792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.971325
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