Restriction of diverse retroviruses by SAMHD1

BACKGROUND: SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcript...

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Autori principali: Gramberg, Thomas, Kahle, Tanja, Bloch, Nicolin, Wittmann, Sabine, Müllers, Erik, Daddacha, Waaqo, Hofmann, Henning, Kim, Baek, Lindemann, Dirk, Landau, Nathaniel R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605129/
https://ncbi.nlm.nih.gov/pubmed/23497255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-26
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