MEK Inhibition Enhances ABT-737-Induced Leukemia Cell Apoptosis via Prevention of ERK activated MCL-1 induction and Modulation of MCL-1/BIM Complex

Recently, strategies for AML therapy have been developed that target anti-apoptotic BCL2 family members using BH3 mimetic drugs such as ABT-737. Though effective against BCL2 and BCL-X(L), ABT-737 poorly inhibits MCL-1. Here we report that, unexpectedly, ABT-737 induces activation of ERK and inducti...

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Détails bibliographiques
Auteurs principaux: Konopleva, M, Milella, M, Ruvolo, P, Watts, JC, Ricciardi, MR, Korchin, B, Teresa, McQueen, Bornmann, William, Tsao, T, Bergamo, P, Mak, DH, Chen, W, McCubrey, J, Tafuri, A, Andreeff, M
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604791/
https://ncbi.nlm.nih.gov/pubmed/22064351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.287
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