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Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans
Phospho-tyrosol-indomethacin (PTI; MPI 621), a novel anti-cancer agent, is more potent and safer than conventional indomethacin. Here, we show that PTI was extensively metabolized in vitro and in vivo. PTI was rapidly hydrolyzed by carboxylesterases to generate indomethacin as its major metabolite i...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3604040/ https://ncbi.nlm.nih.gov/pubmed/23399640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.01.031 |
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