The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies

We have synthesized a novel derivative of indomethacin, phospho-tyrosol-indomethacin (PTI; MPI-621), and evaluated its anticancer efficacy in vitro and in vivo. PTI inhibited the growth of human colon, breast and lung cancer cell lines 6–30-fold more potently than indomethacin. In vivo, in contrast...

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Main Authors: Zhou, Dingying, Papayannis, Ioannis, Mackenzie, Gerardo G., Alston, Ninche, Ouyang, Nengtai, Huang, Liqun, Nie, Ting, Wong, Chi C., Rigas, Basil
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
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Original Manuscript
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616666/
https://ncbi.nlm.nih.gov/pubmed/23338686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs394
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