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Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity

Phospho-nonsteroidal anti-inflammatory drugs (phospho-NSAIDs) are novel NSAID derivatives with improved anticancer activity and reduced side effects in preclinical models. Here, we studied the metabolism of phospho-NSAIDs by carboxylesterases and assessed the impact of carboxylesterases on the antic...

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書誌詳細
主要な著者: Wong, Chi C., Cheng, Ka-Wing, Xie, Gang, Zhou, Dingying, Zhu, Cai-Hua, Constantinides, Panayiotis P., Rigas, Basil
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263964/
https://ncbi.nlm.nih.gov/pubmed/22085648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188508
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