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Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (I(to)) in human atrial myocytes. However, the molecular determinants of acacetin for blocking I(to) are unknown. The present study was designed to investigate the properties and molecular determinants...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wu, Hui-Jun, Sun, Hai-Ying, Wu, Wei, Zhang, Yan-Hui, Qin, Guo-Wei, Li, Gui-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603988/
https://ncbi.nlm.nih.gov/pubmed/23526953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057864
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