Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear if such variability impacts their utility for disease modeling. Here, we show that although low passage female hiPSCs retain the inactive X-chromosome of the somatic...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Mekhoubad, Shila, Bock, Christoph, de Boer, A. Sophie, Kiskinis, Evangelos, Meissner, Alexander, Eggan, Kevin
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603710/
https://ncbi.nlm.nih.gov/pubmed/22560080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.02.014
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker