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Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling
Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear if such variability impacts their utility for disease modeling. Here, we show that although low passage female hiPSCs retain the inactive X-chromosome of the somatic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603710/ https://ncbi.nlm.nih.gov/pubmed/22560080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.02.014 |
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