All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS

Human induced pluripotent stem cell (iPSC)-derived neurons are an attractive substrate for modeling disease, yet the heterogeneity of these cultures presents a challenge for functional characterization by manual patch-clamp electrophysiology. Here, we describe an optimized all-optical electrophysiol...

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Bibliographic Details
Published in:Stem Cell Reports
Main Authors: Kiskinis, Evangelos, Kralj, Joel M., Zou, Peng, Weinstein, Eli N., Zhang, Hongkang, Tsioras, Konstantinos, Wiskow, Ole, Ortega, J. Alberto, Eggan, Kevin, Cohen, Adam E.
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993648/
https://ncbi.nlm.nih.gov/pubmed/29779896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.020
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