The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans

Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly regulated by iron and abundant in iron-starved cells, suggesting a role in iron acquisition. Indeed, loss of Cig1 resulted...

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Autors principals: Cadieux, Brigitte, Lian, Tianshun, Hu, Guanggan, Wang, Joyce, Biondo, Carmelo, Teti, Giuseppe, Liu, Victor, Murphy, Michael E. P., Creagh, A. Louise, Kronstad, James W.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603535/
https://ncbi.nlm.nih.gov/pubmed/23322859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit029
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