A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics

Physiological changes in pregnancy, including changes in body composition and metabolic enzyme activity, can alter drug pharmacokinetics. A semi-mechanistic metabolism model was developed to describe the pharmacokinetics of two cytochrome P450 3A (CYP3A) substrates, midazolam and nifedipine, in obst...

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Main Authors: Quinney, S K, Mohamed, A N, Hebert, M F, Haas, D M, Clark, S, Umans, J G, Caritis, S N, Li, L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603475/
https://ncbi.nlm.nih.gov/pubmed/23835882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.5
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