Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine

AIM: To evaluate the impact of single and repeated doses casopitant on the pharmacokinetics of single dose midazolam and nifedipine (CYP3A substrates) in healthy subjects. The effect on debrisoquine metabolism (CYP2D6 substrate) was also assessed. METHODS: Three open-label studies were conducted in...

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Detalhes bibliográficos
Main Authors: Zamuner, Stefano, Johnson, Brendan M, Pagliarusco, Sabrina, Fina, Paolo, Peroni, Michela, Fiore, Monica, Adams, Laurel M, Fernandes, Sofia A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950988/
https://ncbi.nlm.nih.gov/pubmed/20840445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03729.x
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