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Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity
CYP3A plays an important role in drug metabolism and, thus, can be a considerable liability for drug-drug interactions. Population pharmacokinetics may be an efficient tool for detecting such drug-drug interactions. Multiple models have been developed for midazolam, the typical probe substrate for C...
Shranjeno v:
| izdano v: | J Pharmacokinet Pharmacodyn |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer US
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7652802/ https://ncbi.nlm.nih.gov/pubmed/32772302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09704-1 |
| Oznake: |
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