Effect of CYP2C9 polymorphisms on the pharmacokinetics of indomethacin during pregnancy

BACKGROUND AND OBJECTIVE: CYP2C9 catalyzes the biotransformation of indomethacin to its inactive metabolite O-desmethylindomethacin (DMI). The aim of this work was to determine the effect of CYP2C9 polymorphisms on indomethacin metabolism in pregnant women. METHODS: Plasma concentrations of indometh...

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書誌詳細
出版年:Eur J Drug Metab Pharmacokinet
主要な著者: Shah, Mansi, Xu, Meixiang, Shah, Poonam, Wang, Xiaoming, Clark, Shannon M., Costantine, Maged, West, Holly A., Nanovskaya, Tatiana N., Ahmed, Mahmoud S., Abdel-Rahman, Sherif Z., Venkataramanan, Raman, Caritis, Steve N., Hankins, Gary D.V., Rytting, Erik
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380929/
https://ncbi.nlm.nih.gov/pubmed/30159654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-018-0505-7
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