Effect of CYP2C9 polymorphisms on the pharmacokinetics of indomethacin during pregnancy

BACKGROUND AND OBJECTIVE: CYP2C9 catalyzes the biotransformation of indomethacin to its inactive metabolite O-desmethylindomethacin (DMI). The aim of this work was to determine the effect of CYP2C9 polymorphisms on indomethacin metabolism in pregnant women. METHODS: Plasma concentrations of indometh...

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Detalhes bibliográficos
Publicado no:Eur J Drug Metab Pharmacokinet
Main Authors: Shah, Mansi, Xu, Meixiang, Shah, Poonam, Wang, Xiaoming, Clark, Shannon M., Costantine, Maged, West, Holly A., Nanovskaya, Tatiana N., Ahmed, Mahmoud S., Abdel-Rahman, Sherif Z., Venkataramanan, Raman, Caritis, Steve N., Hankins, Gary D.V., Rytting, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380929/
https://ncbi.nlm.nih.gov/pubmed/30159654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-018-0505-7
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