Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis

BACKGROUND: Temozolomide (TMZ) is widely used for chemotherapy of metastatic melanoma. We hypothesized that epigenetic modulators will reverse chemotherapy resistance, and in this article, we report studies that sought to determine the recommended phase 2 dose (RP2D), safety, and efficacy of decitab...

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Detalhes bibliográficos
Main Authors: Tawbi, H. A., Beumer, J. H., Tarhini, A. A., Moschos, S., Buch, S. C., Egorin, M. J., Lin, Y., Christner, S., Kirkwood, J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603441/
https://ncbi.nlm.nih.gov/pubmed/23172636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mds591
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