Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis

BACKGROUND: Temozolomide (TMZ) is widely used for chemotherapy of metastatic melanoma. We hypothesized that epigenetic modulators will reverse chemotherapy resistance, and in this article, we report studies that sought to determine the recommended phase 2 dose (RP2D), safety, and efficacy of decitab...

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Autors principals: Tawbi, H. A., Beumer, J. H., Tarhini, A. A., Moschos, S., Buch, S. C., Egorin, M. J., Lin, Y., Christner, S., Kirkwood, J. M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603441/
https://ncbi.nlm.nih.gov/pubmed/23172636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mds591
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