Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) reverses the O(6)-methylguanine (O(6)-meG) lesion induced by dacarbazine. Depletion of MGMT can be achieved using O(6)-meG pseudosubstrates. Herein, we report the first phase I experience of the novel O(6)-meG pseudos...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tawbi, H A, Villaruz, L, Tarhini, A, Moschos, S, Sulecki, M, Viverette, F, Shipe-Spotloe, J, Radkowski, R, Kirkwood, J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171007/
https://ncbi.nlm.nih.gov/pubmed/21811257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.285
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados