Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) reverses the O(6)-methylguanine (O(6)-meG) lesion induced by dacarbazine. Depletion of MGMT can be achieved using O(6)-meG pseudosubstrates. Herein, we report the first phase I experience of the novel O(6)-meG pseudos...

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Detalles Bibliográficos
Autores principales: Tawbi, H A, Villaruz, L, Tarhini, A, Moschos, S, Sulecki, M, Viverette, F, Shipe-Spotloe, J, Radkowski, R, Kirkwood, J M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
Materias:
Clinical Study
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171007/
https://ncbi.nlm.nih.gov/pubmed/21811257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.285
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