Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis

BACKGROUND: Temozolomide (TMZ) is widely used for chemotherapy of metastatic melanoma. We hypothesized that epigenetic modulators will reverse chemotherapy resistance, and in this article, we report studies that sought to determine the recommended phase 2 dose (RP2D), safety, and efficacy of decitab...

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Hlavní autoři: Tawbi, H. A., Beumer, J. H., Tarhini, A. A., Moschos, S., Buch, S. C., Egorin, M. J., Lin, Y., Christner, S., Kirkwood, J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603441/
https://ncbi.nlm.nih.gov/pubmed/23172636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mds591
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