From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties

To develop a maturation function for drug glucuronidation in children, that can be used in population and physiologically based modeling approaches, the physiological and physicochemical basis of a semiphysiological glucuronidation function for children was untangled using Simcyp. The results show t...

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Main Authors: Krekels, E H J, Johnson, T N, den Hoedt, S M, Rostami-Hodjegan, A, Danhof, M, Tibboel, D, Knibbe, C A J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603432/
https://ncbi.nlm.nih.gov/pubmed/23887362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.12
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