From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine

New approaches to expedite the development of safe and effective pediatric dosing regimens and first-in-child doses are urgently needed. Model-based approaches require quantitative functions on the maturation of different metabolic pathways. In this study, we directly incorporated a pediatric covari...

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Detalhes bibliográficos
Main Authors: Krekels, E H J, Neely, M, Panoilia, E, Tibboel, D, Capparelli, E, Danhof, M, Mirochnick, M, Knibbe, C A J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603431/
https://ncbi.nlm.nih.gov/pubmed/23887364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.11
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