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Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism
Carboxylesterases (CEs) are ubiquitous enzymes responsible for the detoxification of xenobiotics. In humans, substrates for these enzymes are far-ranging, and include the street drug heroin and the anticancer agent irinotecan. Hence, their ability to bind and metabolize substrates is of broad intere...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603365/ https://ncbi.nlm.nih.gov/pubmed/22127613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-011-1308-9 |
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