Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

The Pax-8 gene, a member of the murine family of paired box-containing genes (Pax genes), is expressed in adult thyroid and in cultured thyroid cell lines. The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Zannini, M, Francis-Lang, H, Plachov, D, Di Lauro, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360331/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1508216/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.9.4230-4241.1992
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