An Engineered PAX3-KRAB Transcriptional Repressor Inhibits the Malignant Phenotype of Alveolar Rhabdomyosarcoma Cells Harboring the Endogenous PAX3-FKHR Oncogene

The t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma tumors (ARMS) creates an oncogenic transcriptional activator by fusion of PAX3 DNA binding motifs to a COOH-terminal activation domain derived from the FKHR gene. The dominant oncogenic potential of the PAX3-FKHR fusion protein is de...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Fredericks, William J., Ayyanathan, Kasirajan, Herlyn, Meenhard, Friedman, Josh R., Rauscher, Frank J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10866659/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.14.5019-5031.2000
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