An Engineered PAX3-KRAB Transcriptional Repressor Inhibits the Malignant Phenotype of Alveolar Rhabdomyosarcoma Cells Harboring the Endogenous PAX3-FKHR Oncogene

The t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma tumors (ARMS) creates an oncogenic transcriptional activator by fusion of PAX3 DNA binding motifs to a COOH-terminal activation domain derived from the FKHR gene. The dominant oncogenic potential of the PAX3-FKHR fusion protein is de...

Descripció completa

Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Fredericks, William J., Ayyanathan, Kasirajan, Herlyn, Meenhard, Friedman, Josh R., Rauscher, Frank J.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2000
Matèries:	Cell Growth and Development
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10866659/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.14.5019-5031.2000
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!